Genes, Free Full-Text

Por um escritor misterioso

Descrição

KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A has a crucial role in gene expression, thus it is associated to pathological conditions when found mutated. KMT2A germinal mutations are associated to Wiedemann–Steiner syndrome and also in patients with initial clinical diagnosis of several other chromatinopathies (i.e., Coffin–Siris syndromes, Kabuki syndrome, Cornelia De Lange syndrome, Rubinstein–Taybi syndrome), sharing an overlapping phenotype. On the other hand, KMT2A somatic mutations have been reported in several tumors, mainly blood malignancies. Due to its evolutionary conservation, the role of KMT2A in embryonic development, hematopoiesis and neurodevelopment has been explored in different animal models, and in recent decades, epigenetic treatments for disorders linked to KMT2A dysfunction have been extensively investigated. To note, pharmaceutical compounds acting on tumors characterized by KMT2A mutations have been formulated, and even nutritional interventions for chromatinopathies have become the object of study due to the role of microbiota in epigenetic regulation.
Genes, Free Full-Text
Human Genome Editing: Science, Ethics, and Governance
Genes, Free Full-Text
IJMS, Free Full-Text
Genes, Free Full-Text
Genes, Free Full-Text
Genes, Free Full-Text
Multiyear Factor VIII Expression after AAV Gene Transfer for
Genes, Free Full-Text
PDF] WEB TOOL , a BioJS component to visualize KEGG Pathways
Genes, Free Full-Text
Stream Download❤️eBook✓ Recombinant DNA: Genes and Genomes - A
Genes, Free Full-Text
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
Genes, Free Full-Text
Progressive Cactus is a multiple-genome aligner for the thousand
Genes, Free Full-Text
Cell-free gene expression Nature Reviews Methods Primers
Genes, Free Full-Text
Genetic Material Definition & Function - Video & Lesson
Genes, Free Full-Text
Epigenetics - Wikipedia
de por adulto (o preço varia de acordo com o tamanho do grupo)