Cells, Free Full-Text

Por um escritor misterioso

Descrição

Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells. The impact of intra-tumor cellular heterogeneity using a label-free approach remains understudied in the context of treatment resistance. Here, we use the sedimentation field–flow fractionation technique to separate, without labeling, cell subpopulations of colorectal cancer cell lines and primary cultures according to their biophysical properties. One of the three sorted cell subpopulations exhibits characteristics of cancer stem cells, including high tumorigenicity in vivo and a higher frequency of tumor-initiating cells compared to the other subpopulations. Due to its chemoresistance, two- and three-dimensional in vitro chemosensitivity assays highlight the therapeutic relevance of this cancer stem cell subpopulation. Thus, our results reveal the major implication of intra-tumor cellular heterogeneity, including cancer stem cells in treatment resistance, thanks to our label-free cell sorting approach. This approach enables—by breaking down the tumor—the study the individualized response of each sorted tumor cell subpopulation and to identify chemoresistance, thus offering new perspectives for personalized therapy.
Cells, Free Full-Text
Cell-free methods to produce structurally intact mammalian
Cells, Free Full-Text
Labile coat: reason for noninfectious cell-free varicella-zoster
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
An illustration of the full-duplex cell-free massive MIMO system
Cells, Free Full-Text
Cell-Free DNA and Apoptosis: How Dead Cells Inform About the
Cells, Free Full-Text
Rapid cell-free characterization of multi-subunit CRISPR effectors
Cells, Free Full-Text
Serial Number Alcohol 120 1.9 6 - Colaboratory
Cells, Free Full-Text
Cell-free DNA tissues of origin by methylation profiling reveals
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Ds Kumar Strömungsmechanik Pdf Kostenloser Download - Colaboratory
Cells, Free Full-Text
Cells, Free Full-Text
Cells, Free Full-Text
Cell-free gene expression: an expanded repertoire of applications
de por adulto (o preço varia de acordo com o tamanho do grupo)